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Triplex DNA and human disease.

John J Bissler¹

¹Department of Pediatrics, Division of Nephrology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA. john.bissler@cchmc.org

Frontiers in Bioscience : a Journal and Virtual Library

|May 9, 2007

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Mutagenesis balances genetic code fidelity and evolution. This review examines how alternative DNA structures, specifically polypurine polypyrimidine mirror repeats, impact genomic stability and are linked to human diseases.

Area of Science:

Genetics
Molecular Biology
Genomic Stability

Background:

Mutagenesis is crucial for genetic code stability and evolution.
Extrinsic factors drive mutagenesis, but intrinsic factors like alternative DNA structures also play a role.
Alternative DNA structures can impact regional genomic stability.

Purpose of the Study:

To review disease-associated polypurine polypyrimidine mirror repeat sequences.
To understand the role of these DNA structures in human diseases.

Main Methods:

Literature review of studies on alternative DNA structures.
Focus on polypurine polypyrimidine mirror repeat sequences.
Analysis of their association with human diseases.

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Main Results:

Polypurine polypyrimidine mirror repeat sequences form alternative DNA structures.
These structures are linked to genomic instability.
Association with various human diseases has been identified.

Conclusions:

Alternative DNA structures, particularly polypurine polypyrimidine mirror repeats, are significant intrinsic factors affecting genomic stability.
These sequences are implicated in the pathogenesis of human diseases.
Further research into these structures may reveal new therapeutic targets.