Related Experiment Video
Updated: Jul 15, 2026

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
Published on: October 18, 2013
AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes
E Dicks1, J W Teague, P Stephens
1Cancer Genome Project, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Unlabelled:
The undertaking of large-scale DNA sequencing screens for somatic variants in human cancers requires accurate and rapid processing of traces for variants. Due to their often aneuploid nature and admixed normal tissue, heterozygous variants found in primary cancers are often subtle and difficult to detect. To address these issues, we have developed a mutation detection algorithm, AutoCSA, specifically optimized for the high throughput screening of cancer samples.
Availability:
http://www.sanger.ac.uk/genetics/CGP/Software/AutoCSA.

