Experience-dependent rescaling of entorhinal grids
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Updated: Jul 15, 2026
Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex
Published on: March 28, 2012
Caswell Barry1, Robin Hayman, Neil Burgess
1Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK.
Abstract:
The firing pattern of entorhinal 'grid cells' is thought to provide an intrinsic metric for space. We report a strong experience-dependent environmental influence: the spatial scales of the grids (which are aligned and have fixed relative sizes within each animal) vary parametrically with changes to a familiar environment's size and shape. Thus grid scale reflects an interaction between intrinsic, path-integrative calculation of location and learned associations to the external environment.
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