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Related Experiment Videos

Subthreshold microstimulation in frontal eye fields updates spatial memories.

Robert L White1, Lawrence H Snyder

  • 1Department of Anatomy and Neurobiology, Box 8108, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, USA.

Experimental Brain Research
|May 9, 2007
PubMed
Summary
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The frontal eye fields play a role in tracking self-generated movements. Weak stimulation created internal eye movement signals without actual movement, supporting corollary discharge theory.

Area of Science:

  • Neuroscience
  • Oculomotor control
  • Cognitive neuroscience

Background:

  • Accurate internal representations of self-generated movements are crucial for behavior.
  • The frontal eye fields (FEF) are implicated in motor control and planning.
  • Understanding corollary discharge signals is key to comprehending sensorimotor integration.

Purpose of the Study:

  • To investigate the role of the frontal eye fields in processing self-generated movements.
  • To determine if internal saccade signals can be induced without overt motor output.
  • To examine the influence of corollary discharge on sensorimotor tasks.

Main Methods:

  • Electrophysiological stimulation of neurons below saccade threshold in the FEF of monkeys.
  • Utilizing an oculomotor delayed response task.

Related Experiment Videos

  • Comparing stimulation effects during memory periods versus before, and across different task conditions.

    • Main Results:

    • Sub-threshold stimulation during the memory period caused saccade endpoint displacements.
    • Displacements were in the opposite direction of saccades evoked by stronger stimulation.
    • The stimulation effect was minimal when animals ignored self-generated eye movements.

    Conclusions:

    • The FEF contribute to accounting for self-generated movements.
    • Weak FEF stimulation can induce internal saccade signals independent of motor output.
    • Corollary discharge signals can be modulated separately from motor commands.