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[Parvovirus B 19 infection during pregnancy]

I Mylonas1, S Gutsche, G Anton

  • 1Frauenklinik München--Klinikum Innenstadt, Ludwig Maximilians Universität, München, Germany. ioannis.mylonas@med.uni-muenchen.de

Zeitschrift Fur Geburtshilfe Und Neonatologie
|May 9, 2007
PubMed

Insights

Parvovirus B19, a virus targeting red blood cell precursors, causes erythema infectiosum in children. It can lead to various severe hematological and non-hematological complications in all age groups.

Area of Science:

  • Virology
  • Immunology
  • Hematology

Context:

  • Parvovirus B19 is a human pathogen belonging to the Parvoviridae family.
  • It specifically infects erythroid precursor cells in the bone marrow.
  • The virus is a common cause of childhood illness and has significant implications for pregnant women.

Purpose:

  • To review the clinical manifestations and complications associated with Parvovirus B19 infection.
  • To highlight the spectrum of hematological and non-hematological sequelae.
  • To discuss the impact of intrauterine Parvovirus B19 infection on fetal development and pregnancy outcomes.

Summary:

  • Parvovirus B19 causes erythema infectiosum (fifth disease) in children and can lead to aplastic crises, chronic anemia, and arthritis in adults.
  • Intrauterine infection poses risks including hydrops fetalis, fetal death, and potential congenital anomalies, although teratogenicity is considered rare.
  • While congenital malformations are possible, parvovirus B19's teratogenic effect is not definitively established, necessitating careful pregnancy monitoring.

Impact:

  • Understanding the diverse clinical spectrum of Parvovirus B19 infection is crucial for timely diagnosis and management.
  • Awareness of potential fetal complications guides obstetric care and monitoring during pregnancy.
  • Ongoing research into vaccine development offers hope for future prevention strategies against Parvovirus B19.

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