Related Experiment Video
Updated: Jul 15, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
[Nuclear receptors: structure and mechanisms of action]
Abstract:
Nuclear receptors are a superfamily of conserved transcription factors with a unique domain structure. Nuclear receptors play an important role in the regulation of ontogeny, sexual maturation, and cell differentiation, as well as in various metabolic processes. Owing to the specifics of hormonal signaling, Drosophila melanogaster provides a promising model subject for studying the function and regulation of nuclear receptors. The review considers modem data on the molecular structure of nuclear receptors and the mechanisms of their interactions with ligands and transcription cofactors. The known functions of nuclear receptors in regulating embryo development and metamorphosis in D. melanogaster are described in detail.
Related Concept Videos
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Intracellular Hormone Receptors
Signal Transduction: Overview
Typically, signal transduction involves three...
Types of Receptors: Internal Receptors
Similar to membrane-bound receptors, the binding of a ligand to the intracellular receptor of causes a conformational change in the...
Regulation of Nuclear Protein Sorting
Internal Receptors
