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Published on: January 7, 2018
50-grams glucose challenge test for screening of gestational diabetes mellitus in high risk pregnancy
Waraporn Juntarat1, Wibool Rueangchainikhom, Sinat Promas
1Department of Obstetrics and Gynecology, Bhumibol Adulyadej Hospital, Phaholyothin Rd, Bangkhen, Bangkok, Thailand.
Objective:
To evaluate the cutoff value of the 1-hr, 50-gram glucose challenge test (GCT) for screening of gestational diabetes mellitus (GDM), in high-risk pregnancy, and to determine the prevalence of GDM in this group.
Study Design:
Descriptive study (Diagnostic test).
Subjects:
Eight hundred and thirty-eight pregnant women, 24-28 weeks, were identified and recruited based on risk indicators between January and October 2004.
Material And Method:
A GCT was performed in this group. All women with plasma glucose value > or = 130 mg/ dl were given a 3-hr, 100-gram glucose tolerance test (OGTT) to diagnose gestational diabetes mellitus using Carpenter and Coustan diagnostic criteria. The receiver-operator characteristic (ROC) curve was used to identify the cut-off value of GCTfor detecting GDM.
Main Outcome Measures:
The cut-off value of GCTfor detecting GDM by using ROC curve with the sensitivity and specificity of various cut-off values.
Results:
The ROC curve identified a GCT value of > or = 140 mg/dl as the cut-off value for detecting GDM, which showed the sensitivity and specificity of 95.3% and 48.6% respectively. The prevalence of GDM in high-risk pregnant women was 20.17% (169/838).
Conclusions:
Recommended threshold of 140 mg/dl used as the cut-off value of 50-gram, 1-hr GCTfor screening GDM in high-risk pregnancy.
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