Related Experiment Video
Updated: Jul 15, 2026
09:53
Gene Editing of Primary Rhesus Macaque B Cells
Published on: February 10, 2023
MamuSNP: a resource for Rhesus Macaque (Macaca mulatta) genomics
Ripan S Malhi1, Brad Sickler, Dawei Lin
1Department of Anthropology, University of Illinois Urbana-Champaign, Urbana, Illinois, United States of America. malhi@uiuc.edu
Plos One
|May 10, 2007
Summary
We developed a new method to identify single nucleotide polymorphisms (SNPs) across the genome of rhesus macaques. This approach generated over 23,000 candidate SNPs, valuable for genetic research and ancestry identification.
Area of Science:
- Genomics
- Bioinformatics
- Primate Genetics
Background:
- Single nucleotide polymorphisms (SNPs) are crucial genetic markers.
- Efficient identification of SNPs across diverse genomic regions is essential for genetic studies.
Purpose of the Study:
- To develop and apply a novel method for identifying a large number of single nucleotide polymorphisms (SNPs) in the Macaca mulatta genome.
- To create a publicly accessible web resource for Macaca mulatta SNPs.
Main Methods:
- Utilized large-scale parallel pyrosequencing technology.
- Integrated advanced bioinformatics tools for SNP identification and analysis.
- Applied the method to the Macaca mulatta genome.
Main Results:
- Generated approximately 23,000 candidate single nucleotide polymorphisms (SNPs).
- Estimated that over 60% of identified SNPs are high-frequency, suitable for quantitative trait loci (QTL) mapping, genetic management, and relatedness studies.
- Identified less frequent SNPs potentially useful for population-specific ancestry identification.
Conclusions:
- The novel method effectively identifies a substantial number of SNPs across the Macaca mulatta genome.
- The generated SNPs offer significant utility for various genetic applications in Macaca research.
- The MamuSNP web resource provides valuable online access to SNP data for the research community.
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