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Updated: Jul 15, 2026

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
Published on: March 4, 2014
Late-onset monomelic amyotrophy in a Caucasian woman
Dharmesh R Patel1, Laurie Knepper, H Royden Jones
1Department of Neurology, Lahey Clinic, 41 Mall Road, Burlington, Massachusetts 01805, USA.
Abstract:
We describe a 53-year-old Caucasian woman with a 19-year history of an evolving amyotrophy confined to her dominant right arm and hand. Although this atypical case of a late-onset monomelic amyotrophy in some respects mimics Hirayama disease or O'Sullivan-McLeod syndrome, it does not conform precisely with either of those disorders. We compare this individual's difficulties and clinical temporal profile to other disorders considered in the differential diagnoses with regard to her evolving clinical setting.
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