Aligned arrays of biodegradable poly(epsilon-caprolactone) nanowires and nanofibers by template synthesis

We demonstrate that the technically simple, low-cost, and rapid method of template synthesis can be used to create arrays of nanowires and nanofibers from the biocompatible, biodegradable polymer poly(epsilon-caprolactone) (PCL). PCL substrates introduced into a standard laboratory oven at temperatures as low as 65 degrees C are able to form nanostructures. Nanostructure morphology can be controlled, and complex patterning can be achieved. Solvent-free and low-temperature fabrications also allow for the encapsulation of therapeutics for sustained release.