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Updated: Jul 15, 2026

Microfluidic Mixers for Studying Protein Folding
Published on: April 10, 2012
Silver(I) mediated folding of a molecular basket
Zhiqing Yan1, Shijing Xia, Matthew Gardlik
1Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
Abstract:
We have investigated Ag(I) mediated folding of a tridentate compound, containing three pyridine flaps tethered to a semirigid scaffold, into a molecular basket, using both experimental and theoretical methods. The basket formation has been shown to be highly favorable in organic media (Delta G degrees = -7.2 kcal/mol), with the assembly process allowing for another ligand to bind preferentially on the outer side.
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