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Updated: Jul 15, 2026
09:31
Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Negative pressure ventilation via diaphragmatic pacing: a potential gateway for treating systemic dysfunctions
Anthony J Yun1, Patrick Y Lee, John D Doux
1Palo Alto Institute, 470 University Avenue, Palo Alto, CA 94301, USA.
Expert Review of Medical Devices
|May 10, 2007
Summary
Programmed diaphragmatic pacing offers a new pulmonary support method using implanted devices. This technology may improve ventilation for conditions like central sleep apnea and chronic hypoventilation.
Area of Science:
- Biomedical Engineering
- Respiratory Medicine
- Neuromodulation
Background:
- Noninvasive positive pressure ventilation has management challenges.
- Chronic hypoventilation affects various patient populations.
- Autonomic dysfunction is linked to sympathetic bias.
Purpose of the Study:
- To introduce programmed diaphragmatic pacing as an alternative ventilatory support.
- To highlight the potential benefits of implantable diaphragmatic pacers.
- To explore applications in central sleep apnea and chronic hypoventilation.
Main Methods:
- Utilizing implanted, rechargeable, programmable neuromodulators.
- Employing negative pressure ventilation via diaphragmatic pacing.
- Investigating closed-loop systems for enhanced functionality.
Main Results:
- Diaphragmatic pacers may overcome issues associated with current ventilation devices.
- Potential for wider adoption in treating central sleep apnea.
- Improved quality of life for patients with amyotrophic lateral sclerosis and chronic hypoventilation.
Conclusions:
- Diaphragmatic pacing is a promising approach for pulmonary support.
- It may alleviate subclinical hypoventilation in aging populations.
- Potential to reduce sympathetic bias and aid autonomic dysfunction management.
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