Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RANTES/CCL5 polymorphisms as a risk factor for recurrent acute rejection.

Bernd Krüger1, Carsten A Böger, Aiman Obed

  • 1Klinik und Poliklinik für Innere Medizin II, University of Regensburg, Regensburg, Germany. bernd.krueger@klinik.uni-regensburg.de

Clinical Transplantation
|May 10, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of gene-alcohol interaction loci influencing blood pressure in 1.1 million individuals from multiple populations.

Research square·2026
Same author

Diagnosis of early kidney allograft rejection: influencing factors in metabolite-based urine analysis.

Frontiers in medicine·2026
Same author

A Prospective Multicenter Luminex-Based Clinical Algorithm to Define Unacceptable HLA Mismatches Before Kidney Transplantation. Consequences on Outcome, Waiting Time, and Wait List Composition.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same author

Acute Rejection With DSA-Negative Severe Microvascular Inflammation in a Kidney Transplant Recipient With an Isolated DPB1*04-Mismatch Successfully Stabilised With Daratumumab.

HLA·2026
Same author

Large-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals.

medRxiv : the preprint server for health sciences·2026
Same author

Neuroendocrine Tumor of the Terminal Ileum Presenting as Refractory Crohn's Disease: A Diagnostic Challenge.

ACG case reports journal·2025

Genetic variations in the RANTES chemokine promoter, specifically -403G/A and In1.1T/C, are linked to increased recurrent acute rejection episodes after kidney transplantation. Further research is needed for long-term outcomes.

Area of Science:

  • Immunogenetics
  • Transplantation immunology
  • Cardiovascular disease genetics

Background:

  • The chemokine system is implicated in acute rejection and atherosclerosis.
  • RANTES promoter polymorphisms (-403G/A, -28G/C, In1.1T/C) influence chemokine expression and cardiovascular disease risk.
  • Investigating these polymorphisms' impact on renal transplant outcomes is crucial.

Purpose of the Study:

  • To determine the association between RANTES promoter polymorphisms and outcomes in renal transplant recipients.
  • To evaluate the influence of specific RANTES gene variants on acute rejection episodes and graft survival.

Main Methods:

  • Genotyping of 261 first-time kidney transplant recipients for RANTES promoter polymorphisms (-403G/A, -28G/C, In1.1T/C) using real-time PCR.
  • Analysis of the correlation between identified polymorphisms and clinical outcomes, including acute rejection, delayed graft function, graft survival, and renal function.

Related Experiment Videos

Main Results:

  • A significantly higher rate of recurrent acute rejection episodes was observed for the RANTES -403G/A (11.1% vs. 31.0%) and In1.1T/C (11.8% vs. 33.0%) polymorphisms.
  • No significant differences in the overall rate of acute rejection were found concerning the RANTES promoter polymorphisms.
  • Delayed graft function, graft survival, and renal function showed no association with the three RANTES polymorphisms studied.

Conclusions:

  • RANTES plays a significant role in kidney transplantation, particularly in recurrent acute rejection.
  • The RANTES -403G/A and In1.1T/C polymorphisms are associated with an increased risk of recurrent acute rejection.
  • Larger studies are required to elucidate the role of these polymorphisms in long-term graft survival and cardiovascular events.