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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

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Updated: Jul 15, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology
03:59

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Breast cancer in the elderly.

Diana Crivellari1, Matti Aapro, Robert Leonard

  • 1Division of Medical Oncology C, Centro di Riferimento Oncologico National Cancer Institute, Aviano, PN Italy. dcrivellari@cro.it

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|May 10, 2007
PubMed
Summary

Elderly breast cancer patients often miss out on treatments despite having a good life expectancy. More clinical trials are needed to ensure evidence-based, age-appropriate care for older women with breast cancer.

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Last Updated: Jul 15, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology
03:59

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Area of Science:

  • Oncology
  • Geriatric Medicine
  • Clinical Trials

Background:

  • Breast cancer incidence is high in women over 65, yet they are often excluded from adjuvant therapy trials.
  • Fit elderly women (e.g., 70+) have significant life expectancy, facing risks of relapse and cancer-specific death.
  • Current treatment aims to improve survival and palliate symptoms, with quality of life being paramount in older adults.

Purpose of the Study:

  • To highlight the underrepresentation of elderly breast cancer patients in clinical trials.
  • To advocate for the development of evidence-based treatment strategies for this demographic.
  • To emphasize the need for cost-benefit analyses of new therapies in older populations.

Main Methods:

  • Review of incidence data from Surveillance, Epidemiology, and End Results (SEER) database.
  • Analysis of life expectancy and potential risks for elderly breast cancer patients.
  • Discussion of current treatment endpoints and emerging therapies like aromatase inhibitors and capecitabine.

Main Results:

  • Elderly patients, despite good health, are frequently excluded from adjuvant clinical trials.
  • Newer therapies (aromatase inhibitors, capecitabine) show promise with potentially lower toxicity.
  • Cost-benefit analysis is crucial for new treatments in the elderly population.

Conclusions:

  • There is an urgent need for clinical trials in both adjuvant and metastatic settings for elderly breast cancer patients.
  • Transitioning from age-based to evidence-based medicine is critical for this group.
  • Optimizing treatment for elderly breast cancer patients requires considering quality of life and functional status.