Related Experiment Video
Updated: Jul 15, 2026

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
Published on: August 13, 2015
[Causes and clinical presentation of physical pain in childhood]
1Opća bolnica Karlovac, Andrije Stampara 3, 47 000 Karlovac. zorazakanj@hotmail.com
Insights
Pediatric pain, a common symptom, causes distress and is undertreated. This review covers pain mechanisms, signs, causes, and differential diagnoses for common childhood pain types.
Area of Science:
- Pediatrics
- Pain Medicine
- Clinical Symptomatology
Context:
- Pain is the most frequent symptom in childhood pathological processes.
- Pediatric pain management is significantly underutilized.
- Children experience physical and psychological distress due to pain.
Purpose:
- To review the pathophysiology of acute and chronic pain in children.
- To outline clinical signs and etiological factors of pediatric pain.
- To provide a differential diagnosis framework for common pain presentations in children.
Summary:
- This review details the pathophysiological mechanisms underlying acute and chronic pain in pediatric patients.
- It explores the diverse clinical manifestations and various causes of pain in children.
- Differential diagnoses for headache, chest pain, abdominal pain, and neck pain are discussed.
Impact:
- Enhances understanding of pediatric pain mechanisms and clinical presentations.
- Aims to improve the recognition and management of pain in children.
- Provides a valuable resource for clinicians diagnosing and treating pediatric pain conditions.
Abstract:
Pain is the most common symptom of pathological process in childhood, presenting with different clinical symptoms. Pain can produce physical and psychical distress in the child, and its management is rarely practiced in pediatric population. The aim of this review is to present patophysiological mechanism of acute and chronic pain in childhood, its clinical signs, the causes of pain, and also differential diagnosis regarding organ systems: headache, chest pain, abdominal pain, and neck pain.
Related Concept Videos
Pain
Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction

