Related Experiment Video
Updated: Jul 15, 2026

Cerebellar Regional Dissection for Molecular Analysis
Published on: December 5, 2020
Cerebellar cortical abiotrophy in Lagotto Romagnolo dogs
T S Jokinen1, C Rusbridge, F Steffen
1Department of Clinical Veterinary Sciences, University of Helsinki, PO Box 57, 00014 Helsinki, Finland.
Abstract:
This case report documents two pathological variations of potentially inherited, cerebellar cortical abiotrophy in two unrelated Lagotto Romagnolo breed dogs. The first dog had an atypical lesion in the cerebellar cortex with depletion of cerebellar granular cell layer and sparing of the Purkinje cell layer. The second case had degenerative changes in both Purkinje and granular cell layers. The clinical picture was similar in both cases presented, although the severity of the signs of cerebellar dysfunction varied.
Related Concept Videos
Cerebellum: Anatomical Regions
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
Cross-bridge Cycle
Animal Mitochondrial Genetics
Secondary Spinal Cord Injury llI: Pathophysiology
Parkinson Disease ll: Pathophysiology
Alterations in Muscle Tone ll
