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Isolation of Murine Embryonic Hemogenic Endothelial Cells
08:56

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Published on: June 17, 2016

[Relationship between hematopoietic development and endothelial cells (hemangioblast or hemogenic

Hui-Yu Yao1, Bing Liu, Ning Mao

  • 1Department of Cell Biology, Institute of Basic Medical Sciences, Beijing 100850, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|May 11, 2007
PubMed

Developmental programs of blood and endothelium are closely correlated and remarkably conserved among species. To categorize the ontogeny relationship between hematopoietic and endothelial lineages, two putative models are presented here. In the yolk sac, hematopoietic and endothelial cells are more likely derived from a common precursor--the hemangioblast. By comparison, the hemogenic endothelium is proposed to characterize the generation of hematopoietic stem cells from mature endothelium in the P-Sp/AGM region. Furthermore, couples of molecules, including Scl, Flk-1 and Runx-1, are involved in formation and subsequent differentiation of the hemangioblast or hemogenic endothelium during embryonic hematopoiesis. In this article, the development of primitive and definitive hematopoiesis, two models associated with development of hematopoietic and vascular endothelial cells as well as molecules associated with development of hematopoietic and endotheliate cells were summaried.

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