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Related Experiment Video

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Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

A system for sharing routine surgical pathology specimens across institutions: the Shared Pathology Informatics

Thomas A Drake¹, Jonathan Braun, Alberto Marchevsky

¹Department of Pathology and Laboratory Medicine, UCLA Medical Center, avid Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

Human Pathology

|May 11, 2007

Summary

A new Web-based system enables pathologists to efficiently search and retrieve pathology specimens from multiple institutions, accelerating cancer research. This informatics tool facilitates finding relevant paraffin blocks for studies.

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DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens

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Area of Science:

Pathology Informatics
Biomedical Informatics
Cancer Research Informatics

Background:

Pathology specimens are crucial for research but difficult to access across institutions.
Existing systems lack efficient methods for searching and retrieving paraffin blocks.
The National Cancer Institute's Shared Pathology Informatics Network (SPIN) program aimed to address this gap.

Purpose of the Study:

To develop a novel Web-enabled system for indexing and retrieving pathology specimens across multiple institutions.
To create a prototype system for identifying paraffin blocks relevant to cancer research.
To overcome challenges in data sharing while maintaining local control and privacy.

Main Methods:

Development of a Web-based informatics system with local data control.
Creation of an eXtensible Markup Language (XML) schema for specimen data.
Implementation of deidentification methods for pathology reports.
Utilizing the Unified Medical Language System (UMLS) for automated data coding.
Establishing robust confidentiality and consent hierarchies.

Main Results:

The prototype system allows Web-based querying of millions of pathology reports from six institutions.
Search and retrieval of relevant pathology reports and paraffin blocks are achieved in seconds to minutes.
Researchers can identify and request specific paraffin blocks from participating institutions.

Conclusions:

The developed system successfully enables efficient, multi-institutional access to pathology specimens.
This informatics solution has significant potential to expand annotated tissue availability for cancer and other disease research.
Future integration with clinical and outcome data will further enhance its research utility.