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Updated: Jul 15, 2026

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Cholecalciferol significantly increases 25-hydroxyvitamin D concentrations in adults with cystic fibrosis
Anne Stephenson1, Michelle Brotherwood, Ronalee Robert
1Toronto Adult Cystic Fibrosis Centre, St Michael's Hospital, Toronto, Canada. stephendona@smh.toronto.on.ca
Background:
Vitamin D deficiency is increasingly being recognized and treated in patients with cystic fibrosis, although the treatment guidelines are not proven and the effectiveness of vitamin D preparations is untested.
Objectives:
The aims of this study were to determine the prevalence of 25-hydroxyvitamin D [25(OH)D] deficiency in a large cohort of adults with cystic fibrosis and to evaluate the effectiveness of supplementation with cholecalciferol.
Design:
In this retrospective cohort design, baseline 25(OH)D concentrations were measured, and the effects of clinical interventions that involved either counseling on compliance or increasing supplemental cholecalciferol on serum 25(OH)D concentrations in those subjects with baseline concentrations
Results:
Of 360 adults with cystic fibrosis, 249 (69%) had baseline 25(OH)D concentrations
Conclusions:
A significant proportion of adults with cystic fibrosis have serum 25(OH)D concentrations
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