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Related Experiment Video

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Swimming Exercise Protocol and Care Methods for Pregnant Rats

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Hermaphroditism in a Sprague-Dawley rat.

R W Diters¹, K A Funk, H Fang

¹Bristol-Myers Squibb Company, PO Box 4755, Syracuse, NY 13221, USA. richard.diters@bms.com

Veterinary Pathology

|May 11, 2007

Summary

A rare case of unilateral true hermaphroditism was found in a Sprague-Dawley rat during a toxicity study. This spontaneous condition, where an animal has both ovarian and testicular tissue, is uncommon in this species.

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Area of Science:

Veterinary Pathology
Developmental Biology
Rodent Models

Background:

Repeat-dose toxicity studies are crucial for drug safety evaluation.
Sprague-Dawley rats are commonly used in preclinical research due to their well-characterized physiology.
Spontaneous conditions in animal models require careful documentation and differentiation from drug-induced effects.

Observation:

A 9-week-old Sprague-Dawley rat, presumed female, exhibited unilateral true hermaphroditism.
This finding was identified during routine necropsy as part of a repeat-dose toxicity study.
No adverse effects related to the study drug were observed in the animal.

Findings:

Unilateral true hermaphroditism is a rare congenital anomaly in rats.
The incidence of true hermaphroditism in rats is very low, with few reported cases in scientific literature.
The observed case was spontaneous and not associated with the experimental treatment.

Implications:

This case highlights the importance of thorough pathological examination in toxicity studies to identify incidental findings.
Understanding the incidence and nature of spontaneous conditions is vital for accurate interpretation of toxicity data.
Documentation of rare conditions contributes to the broader knowledge base of rodent reproductive biology and pathology.