Related Experiment Video
Updated: Aug 18, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
[The effect of abnormal lipid metabolism to glomerular injury]
S Kondo1, N Yoshizawa, S Oshima
1Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Abstract:
To clarify the effect of abnormal lipid metabolism and lipid deposition in glomerular injuries, we conducted clinical and pathological examination of various glomerulonephritis. There was no relationship between serum TC, TG or apo B and renal deposition of apo B or TG in glomerulonephritis. Apo B staining was intense for MCNS but was very weak for FGS. The staining was more intense in higher grade of glomerular injury in IgAN. Apo B demonstrated a specific pattern for MN, MPGN and lupus nephritis. These data suggest that apo B deposition reflects disturbance of glomerular permselectivity of macromolecules including abnormal influx, transport and endocytosis of macromolecules.
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