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09:02
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
Published on: June 5, 2020
BCG-related granulomatous hepatitis.
Adriana Hristea1, Adrian Neacsu, Daniela Adriana Ion
1University of Medicine and Pharmacy Carol Davila, Bucharest. adriana_hristea@yahoo.com
Pneumologia (Bucharest, Romania)
|May 12, 2007
Summary
Bacillus Calmette-Guérin (BCG) immunotherapy for bladder cancer can rarely cause granulomatous hepatitis. This case highlights disseminated BCG infection and its successful treatment with corticosteroids and antituberculosis agents.
Area of Science:
- Immunology
- Oncology
- Infectious Diseases
Background:
- Intravesical Bacillus Calmette-Guérin (BCG) is a standard immunotherapy for superficial bladder cancer.
- Disseminated granulomatous infection is an uncommon but serious complication of BCG therapy.
Observation:
- A 58-year-old man developed fever and jaundice after his 12th BCG instillation.
- Liver biopsy revealed noncaseating granulomatous hepatitis, and PCR confirmed Mycobacterium bovis in liver tissue.
Findings:
- The patient presented with symptoms suggestive of disseminated BCG infection.
- Diagnosis was confirmed via liver biopsy and molecular detection of Mycobacterium bovis.
Implications:
- This case underscores the importance of recognizing granulomatous hepatitis as a potential BCG complication.
- Prompt treatment with corticosteroids and antituberculosis agents led to clinical improvement.
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