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Related Experiment Video

Updated: Jul 15, 2026

An Ex vivo Culture System to Study Thyroid Development

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

Vascular endothelial growth factor in thyroid cyst fluids.

Andrea Hofmann¹, Alois Gessl, Friedrich Girschele

¹Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.

Wiener Klinische Wochenschrift

|May 12, 2007

Summary

Vascular Endothelial Growth Factor (VEGF) is elevated in thyroid cyst fluid, particularly in bloody cysts and adenomatous goiters. This suggests VEGF plays a key role in the development of thyroid cysts.

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Last Updated: Jul 15, 2026

An Ex vivo Culture System to Study Thyroid Development

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Published on: June 6, 2014

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

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Published on: March 15, 2016

A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

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Published on: June 16, 2013

Area of Science:

Endocrinology
Oncology
Pathology

Background:

The development of cystic thyroid nodules is not fully understood.
Vascular Endothelial Growth Factor (VEGF) is hypothesized to be involved in thyroid cyst fluid pathogenesis.

Purpose of the Study:

To investigate the concentration of VEGF in thyroid lesion cyst fluids.
To explore the relationship between VEGF levels and different types of thyroid cysts.

Main Methods:

Ultrasound-guided fine-needle aspiration was used to collect cyst fluids from 24 patients.
High-resolution ultrasonography determined thyroid and cyst volumes.
Solid-phase enzyme-linked immunosorbent assay (ELISA) measured VEGF concentrations.

Main Results:

Elevated VEGF concentrations were observed in cyst fluids from various thyroid nodule origins.
VEGF levels were significantly higher in adenomatous goiter cyst fluid compared to degenerative cysts (P < 0.05).
Bloody cyst fluid showed the highest VEGF levels (P < 0.05), with a significant correlation between thyroid volume and VEGF concentration (P < 0.01).

Conclusions:

Significantly increased VEGF concentrations are present in bloody cyst fluid and adenomatous goiter cyst fluid.
VEGF may play a crucial role in the pathogenesis of thyroid cyst fluid formation.