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[Angiogenesis. Possibilities for therapeutic intervention in rheumatic diseases]
B Maurer1, J H W Distler, F Moritz
1Zentrum für Experimentelle Rheumatologie, UniversitätsSpital Zürich, Gloriastrasse 25, 8091 Zürich.
Zeitschrift Fur Rheumatologie
|May 12, 2007
Summary
Angiogenesis, the growth of new blood vessels from existing ones, is crucial in reproduction and disease. This review explores its role in rheumatic diseases like rheumatoid arthritis and systemic sclerosis.
Area of Science:
- Vascular biology and pathophysiology.
- Endothelial cell biology and extracellular matrix interactions.
Context:
- Angiogenesis, new vessel formation from pre-existing ones, occurs physiologically in adults and pathologically in wound healing, inflammation, and cancer.
- Key mechanisms involve vasodilation, increased permeability, vessel wall destabilization, extracellular matrix degradation, and endothelial cell proliferation/migration.
- This process is regulated by angiogenic and angiostatic factors, leading to vascular tube formation and stabilization.
Purpose:
- To review the role of angiogenesis in the pathogenesis and therapy of rheumatic diseases.
- To discuss therapeutic options for pathologically disturbed angiogenesis in rheumatoid arthritis and systemic sclerosis.
Summary:
- Angiogenesis involves endothelial cell proliferation, migration, and tube formation, followed by stabilization by pericytes and smooth muscle cells.
- While well-understood in carcinogenesis, the role of angiogenesis in rheumatic diseases is less clear.
- Rheumatoid arthritis and systemic sclerosis serve as examples of pathologically disturbed angiogenesis in rheumatic conditions.
Impact:
- Highlights the less understood role of angiogenesis in rheumatic diseases.
- Provides insights into therapeutic strategies targeting angiogenesis in conditions like rheumatoid arthritis and systemic sclerosis.
- Emphasizes the need for further research into angiogenesis-related mechanisms in rheumatology.
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