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QT dispersion and prognosis after coronary stent placement in acute myocardial infarction

Hiroyasu Ueda1, Tomoshige Hayashi, Kei Tsumura

  • 1Department of Cardiology, Ishikiriseiki Hospital, Osaka, Japan. hiroyasu-sayaka@joy.ocn.ne.jp

Clinical Cardiology
|May 12, 2007
PubMed

Insights

Corrected QT dispersion before percutaneous coronary intervention (PCI) predicts major adverse cardiac events and mortality in acute myocardial infarction (AMI) patients. QT dispersion 24 hours post-PCI did not show this association.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Clinical Research

Background:

  • QT dispersion is elevated in acute myocardial infarction (AMI).
  • The prognostic value of QT dispersion post-AMI requires further elucidation.

Purpose of the Study:

  • To prospectively assess if QT dispersion correlates with major adverse cardiac events (MACE) and mortality risk after successful coronary stenting in AMI patients.

Main Methods:

  • 142 AMI patients undergoing successful percutaneous coronary intervention (PCI) were studied.
  • Corrected QT dispersion was measured before and 24 hours after PCI.

Main Results:

  • During follow-up, 21 MACE occurred.
  • Corrected QT dispersion before PCI independently predicted MACE and mortality (HR 2.24 for MACE, 2.71 for mortality per 1 SD increase).
  • Corrected QT dispersion 24 hours post-PCI was not significantly associated with MACE or mortality.

Conclusions:

  • Pre-PCI corrected QT dispersion is a significant predictor of adverse outcomes in AMI patients undergoing successful stenting.
  • Post-PCI QT dispersion does not appear to hold the same prognostic value.
Abstract

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