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[Pregnancy outcome after early amniocentesis]
A Drazancić1, S Skrablin, V Latin
1Klinika za zenske bolesti i porode, Zavod za perinatalnu medicinu, Zagreb.
Jugoslavenska Ginekologija I Perinatologija
|May 1, 1991
Summary
Midtrimester amniocentesis (eACZ) outcomes for 1812 pregnancies are reviewed. Ultrasound guidance significantly reduced spontaneous abortion rates, while previous abortions increased risks. Pathologic karyotypes were more common in older women.
Area of Science:
- Obstetrics and Gynecology
- Prenatal Diagnosis
- Medical Genetics
Context:
- Review of 1812 pregnancies undergoing midtrimester amniocentesis (eACZ) between 1977 and 1989.
- Analysis of indications, karyotypes, and pregnancy outcomes.
- Focus on risks of pathologic karyotypes and spontaneous abortion.
Purpose:
- To assess the safety and efficacy of midtrimester amniocentesis.
- To evaluate the impact of ultrasound guidance on procedure-related complications.
- To determine risk factors for adverse outcomes, including spontaneous abortion and chromosomal abnormalities.
Summary:
- 37 pathologic karyotypes identified, including 24 cases of trisomy 21.
- Spontaneous abortion rate decreased from 3.66% to 1.87% with ultrasound guidance.
- Increased spontaneous abortion rates observed in women with a history of spontaneous abortions.
- Higher incidence of trisomy 21 and other pathologic karyotypes in women aged 37 years and older.
Impact:
- Demonstrates the benefit of ultrasound guidance in reducing amniocentesis-related miscarriage.
- Highlights increased risks for women with prior spontaneous abortions, suggesting careful consideration for this group.
- Provides age-specific risk data for trisomy 21, informing prenatal screening strategies.
- Suggests an age threshold of 37-38 years for considering midtrimester amniocentesis.