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Updated: Jul 15, 2026
07:12
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
Pharmacotherapy options for complex regional pain syndrome
Elon Eisenberg1, Rimma Geller, Silviu Brill
1Rambam Medical Center and Israel Institute of Technology, Pain Relief Unit, Haifa Pain Research Group, Haifa, Israel. e_eisenberg@rambam.health.gov.il
Expert Review of Neurotherapeutics
|May 12, 2007
Summary
Complex regional pain syndrome (CRPS) is a debilitating condition causing severe pain and dysfunction. While treatments exist, many patients still experience inadequate pain relief, highlighting the need for better management strategies.
Area of Science:
- Pain Medicine
- Neurology
- Pharmacology
Background:
- Complex regional pain syndrome (CRPS) is a poorly understood, painful limb disorder.
- It causes significant functional impairment and reduced quality of life.
- Milder forms of CRPS are frequently undiagnosed.
Purpose of the Study:
- To review the pharmacotherapy of complex regional pain syndrome (CRPS).
- To briefly describe the epidemiology, pathogenesis, and clinical manifestations of CRPS.
Main Methods:
- Literature review of controlled trials and existing research on CRPS management.
- Focus on pharmacologic interventions, with brief mentions of other therapies.
Main Results:
- Several treatments show efficacy, including corticosteroids, calcitonin, bisphosphonates, gabapentin, and sympathetic blocks.
- Physical and occupational therapy are also beneficial.
- Current treatments do not provide sufficient pain relief for a significant number of patients.
Conclusions:
- Effective management of CRPS remains challenging due to limitations in current pharmacotherapy.
- Further research is needed to improve pain relief and patient outcomes for CRPS sufferers.
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