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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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Sorafenib: delivering a targeted drug to the right targets

Keith T Flaherty1

  • 1University of Pennsylvania, Abramson Cancer Center, PA 19104, USA. ktflaherty@aol.com

Expert Review of Anticancer Therapy
|May 12, 2007
PubMed

Insights

Sorafenib, approved for advanced kidney cancer, shows promise in other cancers by inhibiting tumor cell signaling and angiogenesis. Further trials are exploring its unique potential in melanoma and liver cancer treatment.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Sorafenib is approved for advanced renal cell carcinoma.
  • It is a multi-targeted agent with potential in other malignancies.

Purpose of the Study:

  • To discuss the clinical trials of sorafenib in renal cell carcinoma, melanoma, and hepatocellular carcinoma.
  • To highlight the knowns and unknowns of sorafenib's efficacy and mechanisms.

Main Methods:

  • Review of Phase II data and correlative studies.
  • Discussion of ongoing Phase III trials in melanoma, hepatocellular carcinoma, and non-small-cell lung cancer.

Main Results:

  • Sorafenib's clinical efficacy may involve inhibition of angiogenesis and tumor cell signaling.
  • Ongoing trials are investigating its role in other cancers.

Conclusions:

  • Sorafenib is a multi-targeted agent with demonstrated efficacy in renal cell carcinoma.
  • Its unique properties warrant further investigation in various cancer types.

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