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Related Experiment Video

Updated: Jul 15, 2026

Targeted Metabolomics on Rare Primary Cells
08:28

Targeted Metabolomics on Rare Primary Cells

Published on: February 23, 2024

Metabolomics as a complementary tool in cell culture.

Soo Hean Gary Khoo1, Mohamed Al-Rubeai

  • 1Department of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, UK.

Biotechnology and Applied Biochemistry
|May 12, 2007
PubMed
Summary

Metabolomics, the global study of metabolites, is a universal tool for systems biology and cell engineering. Method development is key to advancing metabolomics for cell-culture applications and broader scientific use.

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Area of Science:

  • Metabolomics
  • Systems Biology
  • Chemometrics

Background:

  • Metabolomics studies global metabolite changes in biological systems.
  • It integrates metabolite analysis, bioanalytical development, and chemometrics.
  • Current research primarily focuses on plant, microbial, tissue, and biofluid samples.

Purpose of the Study:

  • To explore cell-culture applications of metabolomics.
  • To identify challenges in metabolomics method development.
  • To advance metabolomics as a mature 'omics' science.

Main Methods:

  • Sample preparation techniques.
  • Instrumental analysis protocols.
  • Data processing and bioinformatics pipelines.

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Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry
11:39

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

Published on: June 9, 2019

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
10:44

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures

Published on: March 28, 2017

Related Experiment Videos

Last Updated: Jul 15, 2026

Targeted Metabolomics on Rare Primary Cells
08:28

Targeted Metabolomics on Rare Primary Cells

Published on: February 23, 2024

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry
11:39

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

Published on: June 9, 2019

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
10:44

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures

Published on: March 28, 2017

Main Results:

  • Metabolomics is a vital component of systems biology, reflecting cellular phenotype.
  • Cell engineering benefits from metabolomics' universal applicability.
  • Methodological advancements are crucial for metabolomics growth.

Conclusions:

  • Metabolomics offers diverse potential across industrial, medical, and research fields.
  • Addressing method development issues is essential for metabolomics maturity.
  • Cell-culture metabolomics requires further refinement for broader adoption.