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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
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Related Experiment Video

Updated: Jul 15, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

Adolescent salvia substance abuse.

Sundeep Singh1

  • 1University of Michigan Hospital, Department of Child and Adolescent Psychiatry, Ann Arbor, MI, USA. sundeeps@umich.edu

Addiction (Abingdon, England)
|May 12, 2007
PubMed
Summary

Salvia divinorum, a hallucinogen popular among adolescents, may cause long-term psychiatric effects like déjà vu. Further research is needed to understand the clinical effects of Salvia divinorum use.

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Salvia divinorum is a non-water-soluble hallucinogen gaining popularity among adolescents.
  • It acts as a selective full agonist of kappa-opioid receptors.
  • Its psychotomimetic effects resemble serotonergic agonists and NMDA glutamate antagonists.

Observation:

  • A 15-year-old male with a history of salvia and marijuana use presented with acute mental status changes.
  • Symptoms included paranoia, déjà vu, blunted affect, thought blocking, and slow speech lasting 3 days.
  • These symptoms occurred after recent salvia use.

Findings:

  • Salvia divinorum use is associated with acute effects like depersonalization, laughter, and feelings of levitation, typically resolving within 30 minutes.
  • This case suggests potential undocumented long-term psychiatric effects, such as persistent déjà vu, following salvia use.

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Published on: November 21, 2013

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Last Updated: Jul 15, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

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Implications:

  • The increasing popularity and accessibility of Salvia divinorum warrant further investigation into its clinical effects.
  • Understanding the full spectrum of Salvia divinorum's effects is crucial for adolescent mental health.
  • Clinical guidelines may need updating to address potential long-term psychiatric sequelae.