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Published on: September 6, 2017
[Genetic status of a AB chimeric blood group family]
Bao-Cheng Yang1, Qiong Yu, Yu-Qing Su
1Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen 518035, China.
Abstract:
In order to study the genetic status of a rare chimeric family, some samples of A(3)B(3) family were identified by sequencing of ABO gene; flow-rSSO and PCR-SSP were used to detect loci of HLA-A, B, DRB1 genes, and multiplex amplifying with fluorescence-dye were performed for 16 short tandem repeat (STR) loci. The results indicated that two individuals from A(3)B(3) family contained more than two alleles at ABO gene, HLA-B, DRB1 and some STR loci. In conclusion, analysis of chimeric blood group by using genotyping techniques clearly demonstrating genetic status of this rare chimeric blood group promotes further elucidation of the existing state of specific genetic status.
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