Related Experiment Video

Updated: Jul 15, 2026

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

[Cyclooxygenase 2 and colorectal cancer: therapeutic implications]

Antoni Castells1, Francesc Balaguer, Victòria Gonzalo

  • 1Servicio de Gastroenterología, Institut de Malalties Digestives i Metabòliques, Hospital Clínic, Villaroel 170, 08036 Barcelona, Spain. castells@clinic.ub.es

Gastroenterologia Y Hepatologia
|May 12, 2007
PubMed

Insights

Non-steroidal anti-inflammatory drugs (NSAIDs) show a link to reduced cancer risk. Cyclooxygenase type 2 (COX-2) is a key target, explaining NSAID benefits in cancer prevention and treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Epidemiology

Context:

  • Epidemiological studies suggest NSAIDs reduce the risk of certain cancers.
  • Cyclooxygenase type 2 (COX-2) is identified as a therapeutic target for NSAIDs.
  • COX-2 is frequently over-expressed in various malignant and pre-malignant lesions.

Purpose:

  • To explore the association between NSAID consumption and cancer risk.
  • To investigate the role of COX-2 in neoplasm development.
  • To understand the mechanism behind NSAID efficacy in cancer treatment and prevention.

Summary:

  • Epidemiological data indicate an inverse relationship between NSAID use and the incidence of specific neoplasms.
  • Over-expression of COX-2 in neoplastic tissues supports its role as a therapeutic target.
  • Both traditional NSAIDs and selective COX-2 inhibitors (coxibs) demonstrate efficacy in managing and preventing various cancers.

Impact:

  • Provides mechanistic insight into NSAID-mediated cancer chemoprevention.
  • Highlights COX-2 as a validated therapeutic target for oncological interventions.
  • Supports the clinical application of NSAIDs and coxibs in cancer management strategies.

More Related Videos

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine06:24

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine

Published on: October 13, 2023

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...