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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Cross-reactivity00:42

Cross-reactivity

Overview

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Related Experiment Video

Updated: Jul 15, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Food allergy and anaphylaxis.

Corinne A Keet1, Robert A Wood

  • 1Department of Pediatrics, Johns Hopkins School of Medicine, CMSC 1102, 600 North Wolfe Street, Baltimore, MD 21287, USA.

Immunology and Allergy Clinics of North America
|May 12, 2007
PubMed
Summary

Food allergy is a significant cause of anaphylaxis with rising incidence. Current management focuses on trigger avoidance and epinephrine, with new treatments under investigation.

Area of Science:

  • Immunology
  • Allergy and Immunology
  • Clinical Medicine

Background:

  • Food allergy is a growing global health concern, frequently leading to anaphylaxis.
  • The development of food allergies involves complex immunological mechanisms and tolerance pathways.
  • The clinical presentation and natural history of food allergies vary significantly depending on the specific food allergen.

Purpose of the Study:

  • To provide a comprehensive overview of the current understanding of food allergy.
  • To discuss the clinical characteristics and natural progression of food allergies.
  • To highlight the current management strategies and future therapeutic directions in food allergy.

Main Methods:

  • Review of current scientific literature on food allergy.

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Measuring Local Anaphylaxis in Mice
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Measuring Local Anaphylaxis in Mice

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Basophil Activation Test for Allergy Diagnosis

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Related Experiment Videos

Last Updated: Jul 15, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

  • Analysis of epidemiological trends and risk factors.
  • Synthesis of information on diagnostic approaches and treatment modalities.

    • Main Results:

    • Food allergy is a common trigger for anaphylaxis, with increasing prevalence.
    • Asthma is a significant risk factor for severe food allergy reactions, particularly respiratory failure.
    • Current primary interventions involve allergen avoidance and prompt epinephrine administration.

    Conclusions:

    • Food allergy management relies on avoidance and emergency treatment, with limited therapeutic options currently available outside research.
    • Experimental therapies hold promise for transforming food allergy treatment in the near future.
    • Further research is crucial to understand tolerance mechanisms and develop effective long-term interventions for food allergy.