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Related Experiment Video

Updated: Jul 15, 2026

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

New strategies for combating multidrug-resistant bacteria.

Gerard D Wright¹, Arlene D Sutherland

¹Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1200 Main St W, Hamilton, Ontario, L8N 3Z5, Canada. wrightge@mcmaster.ca

Trends in Molecular Medicine

|May 12, 2007

Summary

Antibiotic resistance, especially multidrug resistance, poses a significant threat. New strategies and chemical discoveries are crucial for developing novel antibiotics and extending the effectiveness of current ones to combat this global health challenge.

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Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

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Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

Area of Science:

Microbiology
Infectious Diseases
Drug Discovery

Background:

Antibiotic resistance is a growing global health concern, impacting both common and emerging pathogens.
Multidrug resistance in bacteria like Staphylococcus aureus, Mycobacterium tuberculosis, and Acinetobacter baumannii necessitates urgent solutions.
Existing treatments are becoming less effective, highlighting the need for novel therapeutic approaches.

Purpose of the Study:

To explore new sources of natural products for antibiotic discovery.
To expand chemical diversity for novel drug development.
To investigate strategies targeting antibiotic resistance mechanisms and microbial virulence.

Main Methods:

Identifying and characterizing new natural products with antimicrobial properties.
Synthesizing novel chemical compounds to enhance antibiotic efficacy.
Investigating inhibitors of bacterial resistance mechanisms and virulence factors.
Analyzing the mechanisms, origins, and distribution of antibiotic resistance.

Main Results:

Advances in natural product discovery are yielding promising chemical leads for new antibiotics.
Expanding chemical diversity is creating new therapeutic options.
Development of inhibitors for resistance mechanisms and virulence factors offers strategies to prolong the utility of existing antibiotics.

Conclusions:

New chemical discoveries and a deeper understanding of antibiotic resistance mechanisms are vital for 21st-century healthcare.
A multi-pronged approach combining novel drug development and resistance-inhibiting strategies is essential.
Continued research is critical to effectively combat the escalating challenge of antibiotic resistance.