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Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Catenins

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

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Updated: Jul 15, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Canonical WNT signaling during kidney development.

Diana M Iglesias¹, Pierre-Alain Hueber, LeeLee Chu

¹Department of Human Genetics, McGill University-Montreal Children's Hospital Research Institute, 4060 St. Catherine West, Montreal, QC, Canada H3Z 2Z3.

American Journal of Physiology. Renal Physiology

|May 12, 2007

Summary

Canonical WNT signaling drives kidney development by controlling ureteric bud branching and nephrogenesis. This pathway

Related Experiment Videos

Last Updated: Jul 15, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Area of Science:

Developmental Biology
Molecular Biology
Genetics

Background:

The canonical WNT signaling pathway is vital for embryonic patterning.
Specific roles in mammalian organogenesis, particularly kidney development, remain unclear.

Purpose of the Study:

To investigate the role of canonical beta-catenin-mediated WNT signaling in mammalian kidney organogenesis.
To identify specific developmental events regulated by WNT signaling during kidney development.

Main Methods:

Utilized mice with a beta-catenin-responsive TCF/betaGal reporter transgene to visualize WNT signaling activity.
Examined WNT signaling in metanephric kidneys during development.
Assessed the impact of a WNT inhibitor (Dickkopf-1) on fetal kidney explants.
Used kidney cell lines derived from ureteric bud and metanephric mesenchyme lineages.

Main Results:

Intense WNT signaling observed in the branching ureteric bud and differentiating nephrogenic mesenchyme.
WNT signaling activity decreased significantly in maturing nephrons and was absent in postnatal kidneys.
WNT2b and WNT4 expression correlated with WNT signaling sites.
Inhibition of WNT signaling reduced ureteric bud arborization.

Conclusions:

Canonical WNT signaling is essential for branching nephrogenesis in the fetal kidney.
Restricted zones of WNT signaling activity orchestrate key developmental events in the kidney.