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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
[Aspects of pleural/pulmonary involvement in systemic lupus erythematosus]
Daniela Adriana Ion1, Răzvan Daniel Chivu, Laura Ioana Chivu
1Facultatea de Medicina, Disciplina Fiziopatologie, Universitatea de Medicină si Farmacie "Carol Davila" Bucureşti.
Abstract:
Systemic lupus erythematosus (SLE) has a wide spectrum of laboratory findings and clinical manifestations. Our objective was to study the pleural/pulmonary involvement in patients with SLE. We have considered 200 patients, diagnosed according to ARA criteria for SLE. Patients were clinically examined, lab test (including immunology) of blood and pleural liquid were performed and also pulmonary biopsies were made. We found that pleurisy was the most frequent involvement, in 12% of patients. More than 50% of necropsies showed a pulmonary involvement; the most frequent aspect was of acute lupus pneumonia, with large hemorrhagic areas. Microscopy showed macrophages loaded with hemosiderin. The alveolar hemorrhage in SLE is due, possibly, to the impairment of coagulation and has a bad prognostic value.
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