Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Association between metastatic lymph node ratio and recurrence after radical resection of thyroid cancer].

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery·2026
Same author

A novel duplication frameshift mutation in the BAG3 gene in a patient with dilated cardiomyopathy.

BMC cardiovascular disorders·2026
Same author

Historical Control Analysis Demonstrates Greater Long-Term Reduction in Plasma Globotriaosylceramide (Gb3) by Venglustat Compared With Placebo or Agalsidase Beta in Male Patients With Classic Fabry Disease.

Molecular genetics & genomic medicine·2025
Same author

Pregnancy-Induced Atypical Hemolytic Uremic Syndrome.

Cureus·2025
Same author

Proteinuria and Palmar Clues: Rediscovering the Renal Face of Syphilis.

Cureus·2025
Same author

Prospective Cohort Study in Alport Syndrome Patients Under Standard Therapy.

Kidney international reports·2025

Related Experiment Video

Updated: Jul 15, 2026

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
07:32

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

How fibroblast growth factor 23 works.

Shiguang Liu1, L Darryl Quarles

  • 1Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

Journal of the American Society of Nephrology : JASN
|May 15, 2007
PubMed
Summary

Fibroblast growth factor 23 (FGF23) regulates phosphate balance. Imbalances in FGF23 cause distinct bone and mineral disorders, impacting vitamin D and calcium levels.

Area of Science:

  • Endocrinology
  • Genetics
  • Nephrology

Background:

  • Phosphate homeostasis is crucial for health, maintained by complex hormonal and renal mechanisms.
  • Fibroblast growth factor 23 (FGF23) is a key phosphaturic hormone, with its circulating levels dictating distinct disease phenotypes.
  • Disorders of phosphate metabolism range from hypophosphatemia to hyperphosphatemia, affecting vitamin D and bone health.

Purpose of the Study:

  • To elucidate the spectrum of disorders related to fibroblast growth factor 23 (FGF23) levels.
  • To highlight the role of FGF23 in phosphate homeostasis and its impact on vitamin D metabolism and bone mineralization.
  • To underscore the significance of understanding the FGF23-regulated bone-kidney axis for diagnosing and treating mineral metabolism disorders.

Main Methods:

More Related Videos

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
05:45

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

Related Experiment Videos

Last Updated: Jul 15, 2026

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
07:32

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
05:45

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

  • Review of hereditary and acquired disorders of phosphate homeostasis.
  • Analysis of clinical manifestations associated with high and low circulating FGF23 levels.
  • Integration of genetic studies and murine models to understand the FGF23 bone-kidney axis.

Main Results:

  • High FGF23 levels lead to hypophosphatemia, reduced 1,25-dihydroxyvitamin D, and rickets/osteomalacia.
  • Low FGF23 levels result in hyperphosphatemia, elevated 1,25-dihydroxyvitamin D, soft tissue calcifications, and hyperostosis.
  • Genetic insights and animal studies have revealed a critical bone-kidney axis governing phosphate and vitamin D metabolism.

Conclusions:

  • Fibroblast growth factor 23 (FGF23) plays a central role in phosphate homeostasis, with opposing effects at high and low concentrations.
  • Understanding the FGF23 regulatory network is essential for managing a spectrum of bone and mineral disorders.
  • Further research into this pathway promises advancements in the diagnosis and treatment of metabolic bone diseases.