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Related Experiment Videos

NGF restores decrease in catalase and increases glutathione peroxidase activity in the brain of aged rats.

G Nisticò1, M R Ciriolo, K Fiskin

  • 1Department of Biology, University of Rome Tor Vergata, Italy.

Neuroscience Letters
|September 2, 1991
PubMed
Summary

Nerve growth factor (NGF) administration restored brain catalase activity in aged rats to young levels. It also boosted antioxidant enzyme activity, suggesting potential for mitigating oxidative stress in aging brains.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Aging Research

Background:

  • Oxidative stress and declining antioxidant enzyme activity are hallmarks of brain aging.
  • Nerve growth factor (NGF) plays a crucial role in neuronal survival and function.

Purpose of the Study:

  • To investigate the impact of subchronic intracerebroventricular nerve growth factor (NGF) administration on antioxidant enzyme activity in aging rat brains.
  • To determine if NGF can restore age-related declines in catalase and glutathione-peroxidase (GSH-Px) activity.

Main Methods:

  • Adult (3-month-old), middle-aged (12-month-old), and aged (24-month-old) rats received daily intracerebroventricular injections of NGF (1 microgram) or vehicle for 28 consecutive days.
  • Catalase and selenium-dependent glutathione-peroxidase (GSH-Px) activity were measured in various brain regions.

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Main Results:

  • NGF significantly increased catalase activity in all studied brain areas of 12- and 24-month-old rats.
  • Catalase activity in aged rats treated with NGF was restored to levels comparable to those in young (3-month-old) rats.
  • NGF administration led to a significant increase in selenium-dependent GSH-Px activity in all brain areas of aged rats compared to young and vehicle-treated controls.
  • Selenium-independent GSH-Px activity remained unaffected by NGF treatment.

Conclusions:

  • Long-term intracerebroventricular administration of NGF effectively increases the activity of key enzymes involved in hydrogen peroxide metabolism in the brains of aged animals.
  • NGF demonstrates potential in counteracting age-related decreases in antioxidant defenses within the brain, specifically targeting catalase and GSH-Px.