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Reversible decrease of fluoride resistant acid phosphatase-positive neurons after herpes simplex virus infection.

R B Tenser1, A L Viselli, D H Savage

  • 1Department of Medicine, Penn State University College of Medicine, Hershey 17033.

Neuroscience Letters
|September 2, 1991
PubMed
Summary
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Herpes simplex virus (HSV) infection reduces fluoride resistant acid phosphatase (FRAP)-positive neurons in mouse trigeminal ganglia for months. This suggests HSV may alter other sensory neuron functions long-term.

Area of Science:

  • Neuroscience
  • Virology
  • Immunology

Background:

  • Herpes simplex virus (HSV) commonly infects sensory neurons in humans and animal models.
  • Understanding the long-term effects of HSV on neuronal function is crucial for managing chronic infections.

Purpose of the Study:

  • To investigate the in vivo effects of HSV infection on neuronal function.
  • To assess changes in trigeminal ganglion neurons following experimental HSV infection in mice.

Main Methods:

  • Experimental infection of mice with Herpes simplex virus (HSV).
  • Analysis of trigeminal ganglion neurons for the presence of fluoride resistant acid phosphatase (FRAP).

Main Results:

  • A decrease in the proportion of FRAP-positive trigeminal ganglion neurons was observed for several months post-infection.

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  • The reduction in FRAP-positive neurons indicates a potential long-term functional alteration.

    • Conclusions:

    • HSV infection can lead to a sustained reduction in specific neuronal markers.
    • These findings suggest that HSV may have broader, long-lasting impacts on sensory neuronal function.