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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Maternal and infant characteristics associated with perinatal arterial stroke in the preterm infant

Manon J N L Benders1, Floris Groenendaal, Cuno S P M Uiterwaal

  • 1Department of Neonatology, Wilhelmina Children's Hospital, Utrecht, The Netherlands.

Stroke
|May 15, 2007
PubMed

Insights

Perinatal arterial stroke (PAS) in preterm infants is linked to antenatal and perinatal factors like twin-to-twin transfusion and hypoglycemia. Imaging shows middle cerebral artery involvement varies with gestational age.

Area of Science:

  • Neonatal neurology
  • Pediatric stroke research
  • Perinatal medicine

Background:

  • Perinatal arterial stroke (PAS) studies often exclude preterm infants.
  • Understanding PAS in this vulnerable population is crucial.

Purpose of the Study:

  • To analyze imaging findings in preterm infants with PAS.
  • To identify antenatal and perinatal risk factors for PAS in preterm infants.

Main Methods:

  • Hospital-based, case-control study.
  • 31 preterm infants with confirmed PAS (cases).
  • Matched controls for comparison.

Main Results:

  • PAS predominantly affected the left hemisphere (61%).
  • Middle cerebral artery distribution was most common.
  • Independent risk factors included twin-to-twin transfusion, fetal heart rate abnormality, and hypoglycemia.
  • Branch involvement patterns varied by gestational age (28-32 vs. >32 weeks).

Conclusions:

  • Preterm PAS is associated with prenatal, perinatal, and postpartum factors.
  • No maternal risk factors were identified.
  • Cerebral artery branch involvement evolves with increasing gestational age.
Abstract

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