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Related Experiment Video

Updated: Jul 15, 2026

Quantification of Endothelial Fatty Acid Uptake using Fluorescent Fatty Acid Analogs

Quantification of Endothelial Fatty Acid Uptake using Fluorescent Fatty Acid Analogs

Published on: August 15, 2025

Fatty acid transport proteins.

Ruth E Gimeno¹

¹Department of Cardiovascular and Metabolic Diseases, Wyeth Research, Cambridge, Massachusetts 02140, USA. rgimeno@wyeth.com

Current Opinion in Lipidology

|May 15, 2007

Summary

Fatty acid transport proteins (FATPs) are multifunctional, impacting energy balance, insulin sensitivity, and skin health. Research highlights their roles in fatty acid uptake and enzymatic activity, with implications for various metabolic processes.

Area of Science:

Biochemistry
Molecular Biology
Physiology

Background:

Fatty acid transport proteins (FATPs) are crucial for cellular fatty acid uptake and activation.
Their diverse roles extend to metabolism, homeostasis, and disease pathogenesis.

Purpose of the Study:

To review recent advancements in understanding FATP functions.
To elucidate the physiological significance of various FATPs.

Main Methods:

Review of experimental data from knockout studies and functional analyses.
Analysis of FATP roles in different tissues like adipose, muscle, and liver.

Main Results:

FATP1 is a key transporter in adipose and muscle tissues, influencing energy homeostasis and insulin resistance.

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FATP5 plays a dual role in hepatic fatty acid uptake and bile acid metabolism.

FATP4 is critical for skin homeostasis, potentially via its acyl-CoA synthetase activity.

Conclusions:

FATP modulation affects energy balance, insulin sensitivity, skin integrity, and bile acid metabolism.
Both transport and enzymatic activities of FATPs contribute to observed phenotypes.
Further research is needed to clarify the roles of FATP2, FATP3, and FATP6.