Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive impairment in multiple sclerosis.

Stefanie Hoffmann1, Marc Tittgemeyer, D Yves von Cramon

  • 1Max Planck Institute of Human Cognitive and Brain Sciences, Leipzig, Germany.

Current Opinion in Neurology
|May 15, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A lateralized pathway for associating nutrients with flavors.

bioRxiv : the preprint server for biology·2025
Same author

Erotic cue exposure increases neural reward responses without modulating temporal discounting.

Imaging neuroscience (Cambridge, Mass.)·2025
Same author

<i>Imaging Neuroscience</i> opening editorial.

Imaging neuroscience (Cambridge, Mass.)·2025
Same author

O<sub>2</sub>-dependent incapacitation of the <i>Salmonella</i> pathogenicity island 1 repressor HilE.

Frontiers in cellular and infection microbiology·2025
Same author

Thalamic opioids from POMC satiety neurons switch on sugar appetite.

Science (New York, N.Y.)·2025
Same author

Dynamic properties in functional connectivity changes and striatal dopamine deficiency in Parkinson's disease.

Human brain mapping·2024
Same journal

Multimodal mapping of balance dysfunction in Parkinson's disease: a consensus roadmap for research and intervention.

Current opinion in neurology·2026
Same journal

Tourette syndrome: brain neurophysiology, circuit dysfunction, and neuromodulation across invasive and noninvasive approaches.

Current opinion in neurology·2026
Same journal

Dystonia: from phenotypes to genetics and therapeutic advances.

Current opinion in neurology·2026
Same journal

What can we learn from eye movements in movement disorders and Parkinson's disease?

Current opinion in neurology·2026
Same journal

Functional movement disorders: diagnosis, pathophysiology, and treatment.

Current opinion in neurology·2026
Same journal

Galectins in the brain: advances in neuroinflammation, neuroprotection and therapeutic opportunities: Erratum.

Current opinion in neurology·2026
See all related articles

Cognitive impairment in multiple sclerosis is a critical issue impacting daily life. Information processing speed tests and magnetic resonance imaging reveal the extent and neural basis of this decline.

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Cognitive impairment in multiple sclerosis (MS) was historically underestimated but is now recognized as crucial for patient adjustment.
  • Recent research emphasizes understanding the neural underpinnings of cognitive deficits in MS.

Purpose of the Study:

  • To review recent advancements in understanding cognitive impairment in MS.
  • To focus on studies exploring the neural correlates of cognitive deficits using magnetic resonance imaging (MRI).

Main Methods:

  • Review of studies utilizing conventional, quantitative, and functional MRI.
  • Analysis of neuropsychological test data, particularly information-processing speed.
  • Correlation of MRI findings with cognitive performance.

Related Experiment Videos

Main Results:

  • Information-processing speed is a sensitive marker for cognitive impairment in MS.
  • Single, speed-focused cognitive tests may effectively screen for overall cognitive decline.
  • Subtle tissue damage in normal-appearing white and grey matter, detected by quantitative MRI, correlates with cognitive impairment severity.

Conclusions:

  • Cognitive impairment in MS results from a complex interplay of tissue destruction, repair, and adaptive functional reorganization.
  • Neuropsychological and advanced MRI findings provide a comprehensive view of cognitive dysfunction in MS.