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Updated: Jul 15, 2026

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Imatinib disposition and ABCB1 (MDR1, P-glycoprotein) genotype

H Gurney1, M Wong, R L Balleine

  • 1Department of Medical Oncology, Westmead Hospital Sydney West Area Health Service, Westmead, New South Wales, Australia. howard_gurney@wmi.usyd.edu.au

Clinical Pharmacology and Therapeutics
|May 15, 2007
PubMed
Summary

Individual differences in drug elimination affect imatinib levels. The ABCB1 gene influences imatinib clearance and steady-state concentrations, potentially reducing dose adjustments for certain patients.

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