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Related Experiment Videos

Nitric oxide synthase-derived plasma nitrite predicts exercise capacity.

Tienush Rassaf1, Thomas Lauer, Christian Heiss

  • 1Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany. trassaf@ukaachen.de

British Journal of Sports Medicine
|May 15, 2007
PubMed
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Plasma nitrite levels increase with exercise and are linked to better exercise performance and vascular function. Impaired nitrite production may limit an individual's exercise capacity.

Area of Science:

  • Cardiovascular Physiology
  • Exercise Science
  • Endocrinology

Background:

  • Nitrite, the primary oxidation product of nitric oxide (NO), is crucial for regulating blood flow and vascular response.
  • Endothelial NO synthase (eNOS) activity influences plasma nitrite levels, particularly under fasting conditions.
  • NO is essential for vasodilation, supporting adequate vascular response during physical exertion.

Purpose of the Study:

  • To determine if the vasculature's capacity to produce nitrite correlates with exercise performance.
  • To investigate the relationship between plasma nitrite levels and endothelial function during exercise.

Main Methods:

  • Plasma nitrite concentrations were measured in 55 healthy subjects before and after an exercise test using chemiluminescence detection.

Related Experiment Videos

  • Endothelial function was assessed via flow-mediated dilation of the brachial artery using high-resolution ultrasound.
  • The role of eNOS in nitrite production was examined using the NOS inhibitor N(G)-monomethyl-L-arginine.

    • Main Results:

    • Exercise significantly increased plasma nitrite levels (p<0.001), with the increase correlating positively with flow-mediated dilation (r = 0.36; p = 0.01).
    • Post-exercise plasma nitrite concentration was positively associated with exercise performance (maximal stress power; r = 0.37; p<0.007) and inversely with age.
    • Multivariate analysis identified both age and post-exercise nitrite concentration as independent predictors of exercise endurance and power.

    Conclusions:

    • Plasma nitrite plays a significant role in hemodynamic adaptation during exercise.
    • A diminished increase in plasma nitrite may restrict exercise capacity.
    • These findings highlight nitrite's importance in maintaining vascular function and performance during physical activity.