Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[TP53 mutations and molecular epidemiology].

Kazunori Otsuka1, Chikashi Ishioka

  • 1Dept. of Clinical Oncology, Tohoku University Hospital, Sendai, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|May 15, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical utility of comprehensive genomic profiling tests using MTB management system at a single center in Japan.

Scientific reports·2026
Same author

Inverse Relation Between Responses to Pembrolizumab Plus Chemotherapy and Subsequent Cetuximab Plus Paclitaxel in Head and Neck Cancer: Role of the Janus Kinase-Signal Transducer and Activator of Transcription Signaling Pathway.

JCO precision oncology·2026
Same author

RAS/BRAF wild-type metastatic high-methylated colorectal cancer has gene expression patterns related to MSI-H and BRAF V600E mutant: a translational research.

Scientific reports·2026
Same author

Attenuated Li-Fraumeni syndrome with TP53 p.R181H in a Japanese patient with metastatic rectal adenocarcinoma: a case report.

Familial cancer·2026
Same author

Harnessing epigenetics: Genome-wide DNA methylation assay for colorectal cancer therapy.

Cancer treatment reviews·2026
Same author

Establishment and Operation of a New Style Clinical Biobank: The Tohoku University Clinical Biobank.

The Tohoku journal of experimental medicine·2026

Mutations in the TP53 gene disrupt tumor suppressor p53 protein function, contributing to cancer development and progression. Analyzing specific TP53 mutations is crucial for understanding their varying oncogenic effects and patient prognosis.

Area of Science:

  • Molecular biology
  • Cancer genetics
  • Oncology

Context:

  • The tumor suppressor p53 protein plays a critical role in cellular stress response, regulating cell cycle, apoptosis, and DNA repair.
  • Loss of p53 function due to TP53 gene mutations is a common event in human cancers, impacting carcinogenesis and tumor progression.

Purpose:

  • To analyze the effects of TP53 mutations on cancer formation and progression from a molecular epidemiological perspective.
  • To highlight the importance of evaluating the oncogenicity of specific TP53 mutations and their correlation with prognosis.

Summary:

  • TP53 is frequently mutated in human cancers (approx. 50%), with varying frequencies across tumor types.
  • The degree of p53 dysfunction varies with mutation type, influencing its impact on cancer.

Related Experiment Videos

  • This study examines specific TP53 mutation spectra and their prognostic correlations, offering insights into interpreting mutation significance.

    • Impact:

    • Provides a framework for understanding the molecular epidemiology of TP53 mutations in cancer.
    • Aids in interpreting the clinical significance of TP53 mutations for patient prognosis.
    • Informs strategies for cancer diagnosis and treatment based on TP53 mutation status.