Related Experiment Video

Updated: Jul 15, 2026

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
06:39

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders

Published on: August 18, 2016

Impaired ventricular electrical stability and sympathetic hyperactivity in patients with multivessel coronary artery

Bunyamin Yavuz1, Ali Deniz, Gulcan Abali

  • 1Department of Cardiology, Kecioren Research Hospital, Ankara, Turkey. byavuzmd@gmail.com

Coronary Artery Disease
|May 15, 2007
PubMed

Insights

Autonomic nervous system activity and ventricular vulnerability are impaired in patients with multivessel coronary artery disease. These findings suggest heart rate variability and QT dynamicity can detect these issues noninvasively.

Area of Science:

  • Cardiology
  • Autonomic Nervous System Research
  • Clinical Electrophysiology

Background:

  • Atherosclerotic disease extent predicts cardiac events in coronary artery disease (CAD).
  • Heart rate variability (HRV) and QT dynamicity are known predictors of sudden death in CAD.
  • These autonomic markers have not been studied in multivessel coronary artery disease (MVD).

Purpose of the Study:

  • To investigate autonomic nervous system (ANS) activity in MVD patients.
  • To assess ventricular vulnerability in MVD.
  • To determine if HRV and QT dynamicity differ in MVD compared to single-vessel disease and controls.

Main Methods:

  • Coronary angiography was performed on 204 patients.
  • Patients were grouped into controls (normal coronary arteries, n=61), single-vessel CAD (n=53), and MVD (n=90).
  • Twenty-four-hour ambulatory ECG monitoring was analyzed for HRV and QT dynamicity parameters.

Main Results:

  • Multivessel CAD patients showed significantly lower SDNN and HFnu, and higher LFnu and LF/HF ratio compared to controls and single-vessel CAD.
  • QTend/RR and QTapex/RR slopes were significantly increased in MVD patients.
  • These results indicate altered ANS activity and increased ventricular vulnerability in MVD.

Conclusions:

  • HRV and QT dynamicity are demonstrably impaired in patients with MVD.
  • These parameters may serve as valuable noninvasive tools for detecting ANS dysfunction and ventricular vulnerability in MVD.
  • Further research can validate these findings for clinical application in MVD risk stratification.
Abstract

More Related Videos

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders05:58

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders

Published on: February 3, 2021

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.