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Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients

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Corneal nerve structure and function in keratoconus: a case report.

Luisa Simo Mannion¹, Cindy Tromans, Clare O'Donnell

¹The University of Manchester, Manchester, United Kingdom.

Eye & Contact Lens

|May 15, 2007

Summary

Keratoconus patients exhibit altered corneal nerves, with thicker stromal fibers and reduced subepithelial density. This study highlights corneal confocal microscopy

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Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Published on: January 24, 2018

Area of Science:

Ophthalmology
Neuroscience
Corneal Imaging

Background:

Keratoconus is a progressive thinning of the cornea.
Corneal nerve alterations may play a role in keratoconus pathophysiology.
In vivo corneal imaging techniques are crucial for understanding corneal diseases.

Observation:

A 24-year-old patient with keratoconus presented with visibly prominent corneal nerves.
Corneal nerve structure and function were assessed using confocal microscopy and aesthesiometry.
Findings were compared to an age-matched healthy control.

Findings:

The keratoconus patient showed thicker stromal nerve fiber bundles (9.8 µm vs. 5.4 µm) and reduced subepithelial nerve fiber density (269.7 µm vs. 1,258 µm) compared to the control.
Corneal sensitivity was significantly reduced in the patient with keratoconus (0.39 gr/mm² vs. 1.59 gr/mm²).
Despite fewer overall stromal nerve bundles, increased tortuosity and diameter contributed to the prominent appearance of corneal nerves.

Implications:

Corneal confocal microscopy is effective for in vivo assessment of corneal nerve morphology in keratoconus.
Altered corneal nerve structure, including increased thickness and tortuosity, is characteristic of keratoconus.
These findings enhance our understanding of the neurobiology of keratoconus and its clinical presentation.