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Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Preventive Healthcare Services01:30

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
Vaccinations01:51

Vaccinations

Overview
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...

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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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Same author

Vaccination against HPV-Associated Neoplasias: Recommendations from the Current S3 Guideline of the HPV Management Forum of the Paul-Ehrlich Society - AWMF Guidelines, Registry No. 082-002 (short version), valid until Dec. 31st, 2018.

Geburtshilfe und Frauenheilkunde·2016
Same author

[Vaccination against HPV-associated neoplasias].

Laryngo- rhino- otologie·2014
Same author

[Prevention of HPV-associated neoplasias by vaccination - short version of the German S3 (level 3) guideline].

Deutsche medizinische Wochenschrift (1946)·2010
Same author

Short version of the German evidence-based Guidelines for prophylactic vaccination against HPV-associated neoplasia.

Vaccine·2009
Same author

[Recurrent respiratory papillomatosis: indication for HPV vaccination?].

Deutsche medizinische Wochenschrift (1946)·2009
Same author

Loss of p53 or p73 in human papillomavirus type 38 E6 and E7 transgenic mice partially restores the UV-activated cell cycle checkpoints.

Oncogene·2007

Related Experiment Video

Updated: Jul 15, 2026

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
13:41

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

[Prophylactic and therapeutic HPV immunization].

M Müller1, L Gissmann

  • 1Deutsches Krebsforschungszentrum Heidelberg, Heidelberg, Deutschland.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|May 15, 2007
PubMed
Summary

Human papillomavirus (HPV) causes tumors and led to a prophylactic vaccine. Future research may focus on developing HPV-specific therapeutic vaccines for cancer treatment.

Area of Science:

  • Virology
  • Oncology
  • Immunology

Context:

  • Papilloma viruses (PV) have been recognized as causative agents of benign and malignant tumors in animals for over a century.
  • The role of PV in human anogenital carcinomas, especially cervical cancer, faced a prolonged period of scientific debate before gaining widespread acceptance.

Purpose:

  • To review the historical understanding of papilloma viruses and their link to cancer.
  • To highlight the development and availability of prophylactic vaccines against human papillomavirus (HPV).
  • To explore the potential for future development of therapeutic vaccines targeting HPV infections.

Summary:

  • Papilloma viruses (PV) are oncogenic agents with a long-documented history in animal tumorigenesis.
  • Significant research efforts culminated in the acceptance of HPV's causal role in human anogenital cancers and the creation of a prophylactic vaccine.

Related Experiment Videos

Last Updated: Jul 15, 2026

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
13:41

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

  • The current focus is shifting towards investigating the feasibility of therapeutic vaccines for HPV-related diseases.

    • Impact:

    • Established the etiological link between papilloma viruses and cancer, paving the way for preventative strategies.
    • Led to the successful development and implementation of a prophylactic HPV vaccine, significantly impacting public health.
    • Opens avenues for novel therapeutic interventions to treat existing HPV infections and associated malignancies.