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Cognitive performance in light current users and ex-users of ecstasy (MDMA) and controls
J F Golding1, D H Groome, N Rycroft
1University of Westminster, London, UK.
The American Journal of Drug and Alcohol Abuse
|May 15, 2007
Summary
Current light users of 3,4-Methylenedioxymethamphetamine (MDMA) show minor cognitive deficits. However, ex-users who abstained for 6 months did not exhibit significant cognitive impairment compared to non-users.
Area of Science:
- Neuroscience
- Psychology
- Addiction Studies
Background:
- Heavy 3,4-Methylenedioxymethamphetamine (MDMA) use is linked to cognitive impairment.
- The cognitive effects of light or past MDMA use remain less understood.
Purpose of the Study:
- To investigate cognitive functioning in current light MDMA users and ex-users.
- To compare cognitive performance between light/ex-MDMA users and non-users.
Main Methods:
- Sixty participants were divided into three groups: light MDMA users, ex-MDMA users, and non-users (20 per group).
- An extensive battery of cognitive tests was administered to assess various cognitive domains.
Main Results:
- Current light MDMA users scored significantly lower on the overall cognitive test battery than non-users (p = .011).
- No significant differences were found in individual cognitive subtests among any groups.
- Ex-MDMA users, abstinent for at least 6 months, showed no significant cognitive differences compared to non-users.
Conclusions:
- Current light MDMA use is associated with a subtle but statistically significant cognitive impairment.
- Cognitive function appears to recover or remain unimpaired in individuals who have ceased MDMA use for at least six months.
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