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Ventilatory and lactic thresholds in subjects with sickle cell trait
L Marlin1, F Sara, S Antoine-Jonville
1Department of Physiology, Laboratoire Actes UPRES-EA 3596, Pointe-A-Pitre Cedex, Guadeloupe. laurentmarlin@hotmail.com
International Journal of Sports Medicine
|May 15, 2007
Summary
Sickle cell trait carriers (SCTc) show normal cardiorespiratory and lactate responses during exercise testing. Ventilatory and lactic thresholds did not differ between SCTc and controls, with the second thresholds coinciding in both groups.
Area of Science:
- Exercise Physiology
- Hematology
Background:
- Sickle cell trait (SCT) is a common hemoglobinopathy.
- Understanding exercise responses in SCT carriers is crucial for assessing physical fitness and potential risks.
Purpose of the Study:
- To compare ventilatory and lactic thresholds between sickle cell trait carriers (SCTc) and healthy controls.
- To determine if the first and second ventilatory thresholds (VT) and lactic thresholds (LT) coincide in these groups during incremental exercise.
Main Methods:
- Seven SCTc and eight control subjects underwent an incremental exercise test (IET).
- Cardioventilatory variables and blood lactate concentrations were measured at rest and during IET.
Main Results:
- No significant differences were found in maximal oxygen uptake (VO2max), ventilatory thresholds, or lactic thresholds between SCTc and controls.
- In both groups, the first VT and LT did not occur at the same exercise intensity.
- The second VT and second LT coincided in both SCTc and control subjects.
Conclusions:
- Sickle cell trait carriers demonstrate typical ventilatory and lactic acid accumulation responses during maximal exercise.
- These findings suggest normal aerobic physical fitness capacity in SCTc individuals.
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